A variety of proinflammatory cells, mediators, and cytokines orchestrate the development of airway hyperresponsiveness, which results in the episodic airflow obstruction characteristic of asthma. As a consequence, modulation of the underlying disease process with antii-nflammatory agents is firmly established as being the cornerstone of successful management. Inhaled corticosteroids are the most potent antiinflammatory agents available and satisfactorily suppress underlying airway inflammation in most individuals. (more…)
The cysteinyl leukotrienes (LTC 4 , LTD 4 and LTE 4 ) are lipid mediators produced from an arachidonic acid precursor following ...
Antihistamines have been shown to be effective in seasonal allergic rhinitis and chronic idiopathic urticaria. They improve qua ...
In the UK, Europe and the USA, montelukast is licensed for once-daily oral administration in adults and is also available as a ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
Despite optimum drug delivery and good compliance with inhaled corticosteroids, many patients experience symptoms and exacerbat ...
Systemic allergic reactions are a relatively common clinical emergency. In their mildest form, they may just manifest as systemic cutaneous reactions with pruritis, allergy urticaria and angioedema. In more severe cases there are cardiorespiratory symptoms such as stridor, wheeze, difficulty in breathing or hypotension. Anaphylaxis has been defined as a ‘severe, life-threatening generalized or systemic hypersensitivity reaction’. The prevalence of systemic allergic reactions is unclear because of the lack of a clear, consistent definition and large prospective population studies. (more…)
Anaphylactic reactions to Hymenoptera venom are relatively uncommon but can be life-threatening: venom immunotherapy is the treatme ...
Definitions of anaphylaxis vary considerably, impeding the comparison of different clinical studies. Different definitions of a ...
It will be helpful for you to have some understanding of the terms that are currently being used by practitioners in the field ...
The safety of immunotherapy has been a constraint on this form of treatment for allergic disease. Although retrospective survey ...
Families frequently do not use their self-injectable adrenaline device, even when their kids is experiencing a potentially life ...
It is very common in asthmatic children where overprotective parents prevent a normal level of exercise to their kids. However, a controlled sport appropriate to the course of their disease is very healthy.
Asthma is an inflammatory disease of the airways characterized by variable bronchial obstruction and reversible, either spontaneously or with treatment, (more…)
Asthma treatment has one main goal to maintain a normal and healthy lifestyle, including exercise and other physical activities. Pe ...
Up to 85% of asthmatics patients have symptoms of wheezing during or after exercise. Moreover, many patients diagnosed with all ...
It is widely knowt that pollen, pollution, smoke can trigger an asthma attack. But one interesting thing is exercise can also trigg ...
Most attacks of asthma, though frightening and uncomfortable, are usually mild and subside within a few minutes with simple treatme ...
This article focuses on symptoms of exercise induced asthma. Exercise can be a trigger factor when asthma is not well control ...
Allergic rhinitis is an inflammatory nasal disorder in which a range of different cells participate. A variety of approaches has been used to monitor nasal inflammation objectively to investigate disease processes and to evaluate the effect of therapeutic intervention. These approaches include nasal lavage, nasal cytology and nasal biopsy, together with the more recently established measurement of nasal nitric oxide (NO) concentration. Although all provide information about nasal mucosal inflammation, the extent of information that can be obtained by each approach, the ease of sampling, and the complexity of sample handling differ. (more…)
After nasal allergen challenge, substance P and CGRP are released into nasal secretions of atopic patients . In allergic rhinit ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
This method of Acoustic Rhinometry is performed by doing the cross-sectional areas of the nasal measures by sending a sound pulse t ...
Non-allergic rhinitis is defined by the absence of positive SPTs or radioallergosorbent test (RAST) to common allergens. Ideall ...
Leukotrienes are present in increased amounts in exhaled breath condensate (EBC) in patients with asthma. So far, no data have ...
Seasonal allergic rhinitis is stimulated by an allergic reaction of human body to pollen and spores. This is much depending on the season and region as they are carried by the wind. Your doctor may recommend you to undergo allergies medication that depends on your type of allergy rhinitis. (more…)
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
Leukotrienes are present in increased amounts in exhaled breath condensate (EBC) in patients with asthma. So far, no data have ...
The Hayband and Qu-Chi Band are a natural alternative to help relieve the symptoms of hay fever. There are many remedies on the ...
As a person who suffered form allergies and have a profession as family physician, I have much sympathy for those struggling with i ...
Do you find yourself feeling miserable, coughing, or sneezing at about the same time each and every year? If you do, it is impo ...
The cross-sensitivity between aspirin and Non Steroidal Anti Inflammatory Drugs in patients who manifest pseudo-allergic reactions to aspirin affecting the respiratory tract occurs because Non Steroidal Anti Inflammatory Drugs, like aspirin, inhibit COX-1, so that arachidonic acid metabolism is diverted towards the 5-lipoxygenase pathway, with resulting increased production of cysteinyl leukotrienes, which mediate the appearance of symptoms such as allergic rhinitis and asthma. Selective inhibitors of Cyclo-Oxygenase-2 or COX-2 were developed primarily to reduce the incidence of adverse events affecting the gastrointestinal tract symptoms, but the possibility that these agents might be less likely to result in other varieties of adverse reaction dependent on COX-1 inhibition has attracted interest. This review examined the evidence for their greater safety in this respect. (more…)
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as one of the popular pain reliever is among regular aspirin, ibuprofen (Advil a ...
This study compared the diagnostic value of intradermal tests and patch tests in 20 patients with non-immediate reactions to pe ...
Suspected drug allergy is not easy to investigate. In the UK, few centers have the necessary facilities and expertise, the evid ...
Patients (and many doctors) frequently use the term ‘allergy’ when referring to any adverse drug reaction, even one that has no fea ...
The prevalence of aspirin-sensitive asthma is uncertain although it may exist in up to 20% of all asthmatics patients. The char ...