Allergic rhinitis and asthma are common comorbidities. Like asthma, the presence of a genetic component in allergic rhinitis has been well established. To identify genetic linkage regions unique to allergic rhinitis, as well as those shared by allergic rhinitis and asthma, a genome screen study was conducted. A total of 295 families in the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) containing 1317 subjects were genotyped for 396 microsatellite markers. The families included had two siblings with DNA available and at least one asthmatic subject. Three definitions of allergic rhinitis were used, two binary and one categorical. To investigate linkages specific to allergic rhinitis (without asthma), linkage analyses were also conducted in 185 families with at most one asthmatic sib. (more…)
This study sought to determine the influence of passive exposure to tobacco smoke during childhood on the results of genetic linkag ...
This study examined the genetic basis of sensitization to house dust mite allergy allergens. A genome scan was conducted usin ...
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Asthmatic children who also have Allergic Rhinitis seem to have higher morbidity and to use more healthcare resources. This was fur ...
Anti-IgE therapy could be particularly beneficial for patients with concomitant asthma and rhinitis as it targets a common factor in the two diseases. Omalizumab is significantly more efficacious than placebo in preventing asthma exacerbations and in improving disease-related quality of life scores when added to standard asthma and rhinitis therapies. (more…)
Patients with severe persistent asthma who are inadequately controlled despite Global Initiative for Asthma (GINA) 2002 step 4 ther ...
Treatment with omalizumab has been shown to reduce serum free IgE concentrations and to have beneficial effects on allergic airway ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and p ...
This study evaluated budesonide formoterol efficacy and safety of a novel asthma management strategy for both maintenance and s ...
Allergic rhinitis is a very common problem associated with poor quality of life, reductions in social and work activities and poor interpersonal relationships. The main goal of the management of allergic rhinitis is to improve the quality of life. Immunotherapy is a specific therapy for allergic rhinitis and several reports have documented the safety and efficacy of this treatment . Safety has been a key issue in immunotherapy and various modalities are being investigated to make allergy immunotherapy more tolerable and safe to administer. (more…)
The safety of immunotherapy has been a constraint on this form of treatment for allergic disease. Although retrospective survey ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, ...
Allergen-specific immunotherapy aims to correct the underlying immune imbalance associated with specific immunotherapy allergic rhi ...
It is now almost a century since the pioneering work of Noon and Freeman was used to successfully treat hay fever symptoms usin ...
Allergen immunotherapy has proven to be effective in the management of allergic disease and is the only treatment that is able ...
Natural history studies with the following design features provide a firm epidemiologic foundation for risk factor assessments and etiologic hypotheses:
(1) long-term cohort studies of a prospective design minimize biases resulting from poor parental recall;
(2) multiple evaluations over time provide important checkpoints during the dynamic period of childhood growth and development; and
(3) the inclusion of objective disease measurements strengthens these studies by validating subjective disease assessments (i.e. questionnaire data). (more…)
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
In the Tucson CRS study, about 50% of young children experienced a period of recurrent wheezing and/or coughing in the first 6 ...
There is much controversy as to the role of allergen exposure for the development of atopic sensitization towards this allergen. Wh ...
Sensitization to pets remains a risk factor for asthma and rhinitis, and can occur in people who have never lived with a pet. S ...
Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its deve ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investigate prospectively the natural course of Atopic Dermatitis to determine factors influencing its prognosis and to analyse the relationship of Atopic Dermatitis with childhood asthma. The Multicenter Allergy Study, a German birth cohort, followed 1314 children from birth to age 7 years. Physical examinations, parental interviews on atopic symptoms and diagnoses, and determination of specific immunoglobulin (Ig)E levels were performed regularly. (more…)
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
Breast milk contains a variety of bioactive substances, among them soluble CD14 (sCD14), which plays an important role in innat ...
Atopic dermatitis is a chronic inflammatory condition of the skin which usually starts in infancy. It is sometimes called ‘atop ...
During recent decades there has been extensive epidemiological research to explore the increasing prevalence of asthma and allergy in childhood. The worldwide variations in the prevalence of these diseases necessitate regional rapport. Furthermore, time-trend analyses with comparable methods are important in order to monitor the rapidly changing prevalence of these atopic diseases. Three cross sectional questionnaire-based studies of asthma and allergy in school children were conducted in the counties of Troms and Finnmark in northern Norway in 1985, 1995 and 2000. (more…)
There have been concurrent increases in the prevalence of obesity and asthma in recent years in New Zealand and other countries ...
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Derm ...
The geographical variation in the prevalence of asthma in children does not coincide with variations in air pollution levels. The i ...
Asthma is a complex syndrome rather than a single disease entity. Different phenotypes with varying prognosis and determinants have ...
A general pattern of factors influencing development of asthma seems to be emerging, including family allergy history/ asthma g ...
Leukotrienes are present in increased amounts in exhaled breath condensate (EBC) in patients with asthma. So far, no data have been reported about leukotriene levels in non-asthmatic patients with Seasonal Allergic Rhinitis. The aim of the study was to find out whether the leukotriene levels in exhaled breath condensate were increased in the non-asthmatic adult patients with Seasonal Allergic Rhinitis both during and after the pollen season in comparison with healthy controls, and to assess changes in leukotriene levels after the pollen season. Twentynine non-asthmatic adult patients with Seasonal Allergic Rhinitis and 50 healthy non-smoking controls underwent measurement of exhaled leukotrienes in the exhaled breath condensate during and after the pollen season. Spirometry, skin-prick tests and total IgE were also evaluated. (more…)
Some features seem to be common to severe asthma and Chronic Obstructive Pulmonary Disease with reversibility of airflow limita ...
A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice defic ...
Seasonal allergic rhinitis is stimulated by an allergic reaction of human body to pollen and spores. This is much depending on ...
Adjusting the inhaled glucocorticoid dose based on indices of airway inflammation has been proposed as a means of achieving more ef ...
Treating allergic rhinitis may have a downstream effect on concomitant asthma and this may be due to attenuation of the underlying ...
Atopic Dermatitis is a chronic relapsing skin disease. Several investigations concerning the long-term prognosis of Atopic Dermatitis in children and teenagers have been performed but there are few data for adults. The aim of this study was to investigate the prognosis and prognostic factors in adult patients with Atopic Dermatitis using a long-term follow-up (25–38 years). A follow-up questionnaire was sent to 922 Atopic Dermatitis patients examined in an out-patient clinic between 1960 and 1973 among 1366 registered patients with Atopic Dermatitis. The patients were aged 20 years or older when they visited the clinic and 45 years or older when they answered the follow-up questionnaire. (more…)
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
The prevalence of atopic dermatitis is increasing in Western societies. The hygiene hypothesis proposes that this is due to red ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
Topical corticosteroids are the usual therapy for patients with atopic dermatitis, but prolonged use can result in skin atrophy ...
Atopic dermatitis is a chronic inflammatory condition of the skin which usually starts in infancy. It is sometimes called ‘atop ...