Allergic rhinitis and asthma are common comorbidities. Like asthma, the presence of a genetic component in allergic rhinitis has been well established. To identify genetic linkage regions unique to allergic rhinitis, as well as those shared by allergic rhinitis and asthma, a genome screen study was conducted. A total of 295 families in the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) containing 1317 subjects were genotyped for 396 microsatellite markers. The families included had two siblings with DNA available and at least one asthmatic subject. Three definitions of allergic rhinitis were used, two binary and one categorical. To investigate linkages specific to allergic rhinitis (without asthma), linkage analyses were also conducted in 185 families with at most one asthmatic sib. (more…)
This study sought to determine the influence of passive exposure to tobacco smoke during childhood on the results of genetic linkag ...
This study examined the genetic basis of sensitization to house dust mite allergy allergens. A genome scan was conducted usin ...
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
A previous genome-wide screen for mite-sensitive atopic dermatitis asthma in Japanese families indicated linkage to chromosome 5q33 ...
Asthmatic children who also have Allergic Rhinitis seem to have higher morbidity and to use more healthcare resources. This was fur ...
This study examined the genetic basis of sensitization to house dust mite allergy allergens. A genome scan was conducted using 603 microsatellite markers in 82 nuclear families (366 individuals) of German, British and Portuguese origin with at least two affected siblings. Sensitization to Dermatophagoides pteronyssinus was assessed by determining specific IgE antibody levels detected by immunochemiluminometric assay and immunosorbent assay and categorized as positive or negative relative to a predetermined cut-off point. (more…)
Allergic rhinitis and asthma are common comorbidities. Like asthma, the presence of a genetic component in allergic rhinitis ha ...
Many people are under impression that allergy and asthma disease had genetic or heredity factors playing major role as medium o ...
Atopic Dermatitis is considered to be one of the first manifestations in the atopic march. The aim of this study was to investi ...
CD14 is part of the receptor complex for endotoxin, which is a component of tobacco smoke. The CD14 gene is located on chromoso ...
The manifestations of asthma and allergy are the result of both genetic predisposition and environmental factors. This relation ...