The airway circulation has many potential roles in asthma. The vasculature has a major influence on upper airway patency in nasal infection and atopic responses. Given its responsiveness to provocative stimuli in asthma and vasoconstrictive and antiproliferative response to corticosteroids, the bronchial circulation is likely to be a future target for novel asthma therapies. (more…)
Local micro environmental factors are crucial in determining both susceptibility to vascular remodeling and the extent of angio ...
Vascular Endothelial Growth Factor (VEGF), originally described as a vascular permeability factor generating tissue oedema, has be ...
Eosinophil infiltration of the mucosa is a feature of asthmatic airways. Their adhesion to bronchial epithelial cells has been ...
Acute inflammatory response constitute the first line of defense against infection pathogenesis and how immune system works as ...
IgE plays an important role in allergic asthma. Reducing IgE in the airway mucosa should reduce airway inflammation. Omalizumab has ...
Acute inflammatory response constitute the first line of defense against infection pathogenesis and how immune system works as well as the initial stage in restoring injured tissue to normalcy. Acute inflammation is recognized by redness, swelling, heat and pain in the affected area. These symptoms stem from a multitude of events taking place within the inflamed site. The humoral arm of the immune response, including circulating antibodies and the complement system, is activated. (more…)
Once it is tethered onto the venule wall, the neutrophil or other leukocyte comes into contact with a wide variety of inflammatory ...
Some of the immediate sequelae of injury are uncomfortably familiar: Soon after an injury occurs, the affected site and its sur ...
Neutrophils make up an army of more-or-less identical circulating phagocytes that are poised to respond quickly and in vast numbers ...
The response to injury usually begins with dilatation of small blood vessels in and around the injured site (figure bellow). Th ...
The airway circulation has many potential roles in asthma. The vasculature has a major influence on upper airway patency in nasal i ...