Some features seem to be common to severe asthma and Chronic Obstructive Pulmonary Disease with reversibility of airflow limitation. The neutrophil chemoattractant leukotriene B 4 (LTB 4) may play a role in Chronic Obstructive Pulmonary Disease and in some forms of asthma. In this study, 55 smokers with no disease, Chronic Obstructive Pulmonary Disease (with or without bronchodilator reversibility of airflow limitation) or asthma underwent measurement of LTB 4 in sputum supernatants and exhaled breath condensate asthma (EBC). Both Chronic Obstructive Pulmonary Disease and asthma patients had higher levels of LTB 4 than control subjects; patients with asthma or reversible Chronic Obstructive Pulmonary Disease exhibited significantly higher levels of LTB 4 than those with irreversible Chronic Obstructive Pulmonary Disease. (more…)
Leukotrienes are present in increased amounts in exhaled breath condensate (EBC) in patients with asthma. So far, no data have ...
The cysteinyl leukotrienes (LTC 4 , LTD 4 and LTE 4 ) are lipid mediators produced from an arachidonic acid precursor following ...
A role for Leukotriene B4 in the induction of airway hyper-responsiveness was explored through the use of transgenic mice defic ...
Adjusting the inhaled glucocorticoid dose based on indices of airway inflammation has been proposed as a means of achieving more ef ...
With the help of well-trained and experienced pulmonary function technicians, children as young as 4 to 5 years of age should b ...
Acetylcholine is a neurotransmitter of the nerve vagus, the functional effects mediated by binding to muscarinic receptors. Results from stimulation of acetylcholine on the contraction of myoepithelial cells around bronchial submucosal glands and thus to acetylcholine airway obstruction may bronchial provocation tests in the measurement of bronchial hyperresponsiveness may be used with others. (more…)
Toll-like receptors (TLRs) act as receptors for numerous stimuli of immune cells, including bacterial cell wall constituents (l ...
The way in which pathogens spread through the body is influenced to some extent by whether they live intra-cellularly, extra-ce ...
Adenosine is a nucleoside and consists of adenine in glycosidic linkage with ribose. Most adenosine is derived from cleavage of ade ...
The response to injury usually begins with dilatation of small blood vessels in and around the injured site (figure bellow). Th ...
The cysteinyl leukotrienes (LTC 4 , LTD 4 and LTE 4 ) are lipid mediators produced from an arachidonic acid precursor following ...
Classification of bronchial asthma can be based on age, etiology, associated characteristics, or severity. Classifications based on severity have been primarily designed as an approach to asthma treatment. Thus, management of mild intermittent disease may require only bronchodilator treatment, but frequent attacks with or without persistent mild symptoms require a comprehensive approach to controlling inflammation as well as bronchodilator treatment. Severe asthma can become a major clinical problem that requires specialist care and many different approaches to asthma attack treatment. (more…)
Allergic rhinitis is a high-prevalence disease. This high prevalence translates into a high cost to society in terms of overall ...
The two strongest risk factors for asthma in childhood are a family history and immediate hypersensitivity to common allergens. ...
If you have sinusitis, one of the displeasing aspects of sinusitis is dizziness condition that comes with it. Symptoms of sin ...
Asthma is a continuing problem for healthcare, particularly in the industrialized world. Some 150 million people are estimated ...
Treatment of allergic diseases in childhood presents unique challenges, as both the beneficial effects and the detrimenta ...
Atopy can be determined as such the production of specific IgE response to common exposure to environmental allergens like dust mites, grass and cat or pets. Living with atopic allergic diseases such as asthma, allergic rhinitis linked, and eczema, but not everyone with atopy develops clinical manifestations of allergy and not everyone can be detected in clinical allergy syndrome, atopic diseases, it has been tested for specific IgE for a wide range of environmental allergens. This is especially true for asthma. (more…)
About twenty percent of patients who have common allergic rhinitis are also having perennial allergic rhinitis symptoms. This f ...
If someone has allergies, and it is particularly food allergies, does it change his or her quality of life? The effects of a ...
Specific immunotherapy has been widely used to treat allergic rhinitis symptoms. As with any other form of specific immunotherapy, ...
Treatment of allergic diseases in childhood presents unique challenges, as both the beneficial effects and the detrimenta ...
In 2004, there were 2.4 million children aged 5 to 14 years, or 5.9% of this population group, with a self-reported asthma atta ...
Britain is one of the countries most affected by asthma: has 5.4 million people on asthma treatment, of which 1.1 million are children. Every day there three people die from asthma, but 90% of these deaths could be avoided. (more…)
More severe asthma can persist from childhood into adulthood without remission. Another important tendency in the natural histo ...
Perhaps one day you have experienced chronic fatigue, insomnia, tender points and pain in your muscle all over your body? Do no ...
In 2004, there were 2.4 million children aged 5 to 14 years, or 5.9% of this population group, with a self-reported asthma atta ...
What is Flu? Influenza, commonly known as “the flu,” is a contagious disease caused by a virus. It can cause mild to severe ...
Atopy can be determined as such the production of specific IgE response to common exposure to environmental allergens like dust mit ...
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Anticholinergic agents, including nebulized glycopyrrolate, a potent but non-selective muscarinic receptor blocker, have been found to be effective bronchodilators in patients with chronic obstructive pulmonary disease, who have limited reversibility. The effect in asthmatic patients has not been studied. (more…)
The sensory neuropeptides substance P and neurokinin A (NKA) are members of the tachykinin family, present within pulmonary sensory ...
Regular use of ß-agonists has been known to lead to tolerance to their bronchodilator effects. It is not known how quickly toleranc ...
Leukotrienes can be found in the airway and urine following both spontaneous exacerbations of asthma and acute exposure to bron ...
The role of oral and inhaled corticosteroids in the management of acute asthma is well known. This study compared the effects of in ...
Lidocaine is a local anaesthetic that possesses the ability to potently shorten eosinophil survival. This study assessed the sa ...